The stadium is often referred to by its unofficial nickname The Big A, coined by Herald Examiner Sports Editor, Bud Furillo. It is the fourth-oldest active ballpark in the majors, behind Fenway Park, Wrigley Field, and Dodger Stadium, and hosted the All-Star Game in 1967, 1989, and 2010.

ARTIC (Anaheim Regional Transportation Intermodal Center) servicing the Metro link Orange County Line and Amtrak Pacific Surf liner, is located nearby on the other side of State Route 57 and accessed through the Douglass Road gate at the northeast corner of the parking lot. The station provides convenient access to the stadium, the nearby Honda Center, and Disneyland from various communities along the route, which links San Luis Obispo, Los Angeles, and San Diego. The Anaheim Resort Transit stops at the center along with Orange County Transportation Authority buses.

Aside from professional baseball and football, Angel Stadium has hosted high school and college football games, the short-lived World Football League, two crusades by Evangelist Billy Graham, nearly 20 consecutive annual crusades by Evangelist Greg Laurie, Eid el Fitr celebrations,and concerts, and 2 to 3 AMA Supercross Championship races a year.

The stadium also houses the studios and offices of the Angels' owned and operated flagship radio station, KLAA (830 AM).